Sequence-Structure alignment of the 11 structurally characterised distinct GPCRs

Here is a joy formatted alignment of the (now) 11 sequence distinct rhodopsin-like GPCR structures - I've selected a representative for those for which there are multiple structures known - usually those that are most complete in terms of lack of disordered loops, etc. The alignment is quite unstable in parts, and several regions are open to interpretation.....

The structures are:

1. 3uon - human muscarinic M2 receptor
2. 4daj - rat muscarinic M3 receptor
3. 3rze - human histamine H1 receptor
4. 2rh1 - human beta-2 adrenergic receptor
5. 2vt4 - turkey beta-1 adrenergic receptor
6. 3pbl - human dopamine D3 receptor
7. 2ydv - human adenosine A2a receptor
8. 3v2w - human sphingosine-1-phosphate receptor
9. 3odu - human CCR4 receptor
10. 2i35 - bovine rhodopsin
11. 2z73 - squid rhodopsin

The next to be released structures will almost certainly be the mu-opioid receptor (PDB code 4DKL) and the kappa-opioid receptor (PDB code 4DJH), which are on hold awaiting publication.

                           10        20        30        40        50  
3uon   (  20 )                                             tfevvfivl
4dajA  (  64 )                                             iwqvvfiaf
3rze   (  28 )                                                 mplvv
2rh1   (  29 )                                            devwvvgmgi
2vt4A  (  40 )                                               weagmsl
3pblA  (  32 )                                                   yal
2ydv   (   3 )                                             imgssvYit
3v2w   (  17 )           sdyvnydIIvrHYnyTgklnisa                ltsv
3oduA  (  27 )            pçfre-------------------------enanfnkiflpt
1u19A  (   1 )            mnGtegpnfyVPfsnktgvVrsPFeapQyyLaepwqFsmlAa
2z73A  (   9 )         etwwyNpsIvVhpHWref--------------dqvpdavYyslGi
                                                               aaaaa

                           60        70        80        90        100 
3uon   (  29 )    vagslSlvTiigNilVmvSIkvnrhLqtvnnyflfSLAcADliiGvfSMn
4dajA  (  73 )    ltgflAlvTiigNilVivAFkvnkqLktvnnyFllSLAcADliIGviSMn
3rze   (  33 )    vlsticlvTvglNllVlyAvrserkLhtvGnlYIvsLSvADliVGavVMp
2rh1   (  39 )    vmslivlaIvfgNvlVitAIakferLqtvtnyFItsLAcADlvMGlaVVp
2vt4A  (  47 )    lmalVvllIvagNvlViaAigstqrLqtltnlFItsLAcADlvvGllVVp
3pblA  (  35 )    sYcalilaIvfgNglVcmAVlkeraLqtttnyLVvsLAvADllvAtlVMp
2ydv   (  12 )    vElaiavlAilgNvlVcwAvwlnsnLqnvtnyFVvsAAaADilVGvlAIp
3v2w   (  51 )    vfiliCcfIileNifvlltiwktkkFhrpMYyFIgnLAlSDllaGvaYta
3oduA  (  44 )    iYsiIfltGivgNglvilvMgyqkklrsmtdkYRlhLSvADllFVitLpf
1u19A  (  43 )    yMflLimlGfpiNflTlyVTvqHkkLrtplNyILlnLAvADlfMVfg-GF
2z73A  (  40 )    fIgiCgiiGcggNgiViyLFtktksLqtpanmFiinLAfSDftFSlvNGf
                  aaaaaaaaaaaaaaaaaaaaaa      aaaaaaaaaaaaaaaaaa aaa

                           110       120       130       140       150 
3uon   (  79 )    lytlytvi-gyWplgpvvÇdlWlalDYvVSNAsVmNLliiSfdryfcvtk
4dajA  ( 123 )    lFttyiim-nrWalgnlaÇdlwLSiDYvASNAsVmNLlvISfDryfsitr
3rze   (  83 )    mnilyllm-skwsLgrplÇlfWLSmDYVASTASIfSVfiLCiDryrsvqq
2rh1   (  89 )    fgaahilm-kmWtfgnfwçefWTSiDVlCVTASIeTLcvIAvdryfAIts
2vt4A  (  97 )    fgatlvvr-gtWlwgsflçelWTSlDVlCVTAsIeTLcvIAiDrylaits
3pblA  (  85 )    wvvylevtggvWnfsricÇdvFVTlDVmMcTAsIwNLCaISidRytAVvm
2ydv   (  62 )    faiaIst---GfçaaçhgÇLfiACfVLVLTASSIfSLlaIAiDryiairi
3v2w   ( 101 )    Nlllsga--tTykLtPaqWFlREGsMFvALSASVfSLlaIAieryitmlk
3oduA  (  94 )    WavDAva---nWyfgnflÇkaVHviYTVNlYSSVwILAfISlDRylAiVh
1u19A  (  92 )    tTTlyTSlhGyFvfgptGÇnlEGffATLGGEIaLWSLvvLaieRyvvVck
2z73A  (  90 )    plMtiSCflkkWifgfaaÇkvYGfiGGiFGFMsIMTMAMiSiDrynViGr
                  aaaaaaa        aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa  

                           160       170       180       190       200 
3uon   ( 128 )    pltypvk---rttkmAgmmiaaAwvlSfilwapaIlfwqfivg-------
4dajA  ( 172 )    pltyrak---rttkrAgvmiglAwviSfvlWApaIlfwqyfvg-------
3rze   ( 132 )    plrylky---rtktrAsatilgawflSfl-WvipIlgwnh          
2rh1   ( 138 )    pfkyqSl---ltknkArviilmvwivSgltSflpIqmhwyr-----athq
2vt4A  ( 146 )    pfryqsl---mtrarAkviictvwaiSalvSflpImmhwWr-----dedp
3pblA  ( 135 )    pvhyqhgtgqsscrrValmitavwvlAfaVSc-pLlfgfNtTg-------
2ydv   ( 109 )    plryngl---vtgtrAkgiiaicwvlSfaIGltPmlgwnnÇgqp--kegk
3v2w   ( 156 )               nnfrlfllisacwviSlilGglPimgwn-----------
3oduA  ( 141 )    atn----sqrprkllAekvVyvgVwipAlllT-ipDfif-Anvsead---
1u19A  ( 142 )    pmsn----frfgenhaimgvafTwvmAlaCAapPlvgwSrYIPE------
2z73A  ( 140 )    pmaas---kkMshrrAfimiifVwlwSvlwAigPifgwGaYtLE------
                              aaaaaaaaaaaaaaaaaaa                   

                           210       220       230       240       250 
3uon   ( 168 )    ----vrtVedgeÇyIqff------snaavtfgtAiaaFylpviiMtvlyw
4dajA  ( 212 )    ----krtVppgeÇfIqfl------septitfgtAiaaFymPvtiMtilyw
3rze   ( 175 )           rredkÇeTdfy------dvtwfkvmtaiinFylPtllMlwfya
2rh1   ( 180 )    eAinÇyae-etçÇdff--------TnqayaiasSivSFyvplviMvfvYs
2vt4A  ( 188 )    qAlkçyqd-pgçÇdfv--------TnrayaiasSiiSFyipLliMifval
3pblA  ( 177 )    --------dptvÇsIs---------npdFViySSvvSFylPfgvTvlvya
2ydv   ( 154 )    ahsqgÇgegqvAÇlFedVV-----pmnYMVyfNffaCVlvPlllMlgvyl
3v2w   ( 184 )    ----ÇisalssÇSTVLP-------LYhkhYIlfCTtvFtllllsIvilYc
3oduA  ( 182 )    --------dryiÇdrfyp---ndlwvvvfqfqhimvglilPgivIlsCyc
1u19A  ( 182 )    -------GMQCSÇGIDYYTpheetnNesFViyMfvvHfiiPlivIffcyg
2z73A  ( 181 )    -------GVLCNÇSFdYIsr--dsttrsNIlcMFilGffgPiliiffCyf
                                            aaaaaaaaaaa aaaaaaaaaaaa

                           260       270       280       290       300 
3uon   ( 208 )    hisrasksri                   pppsrekkvtrtilaIllaFi
4dajA  ( 252 )    rIyketek                       like   aqTlsaIllaFi
3rze   ( 212 )    kIykaVrqhc                   lhmnrerkaakQLgfIMaaFi
2rh1   ( 221 )    rVfqeakrql                   kfclkeHkaLktlgiIMgtFt
2vt4A  ( 229 )    rvyreakeq                       irehkalktlgiImgvFt
3pblA  ( 210 )    rIyvvlkqrrrk-----------------gvplrekkatqMVaiVlgaFi
2ydv   ( 199 )    rIflaarrqlkqmesq             stlqkevhaakSLaiIvglFa
3v2w   ( 223 )    riyslvrtr                   asrssenvaLlkTViiVLsvFi
3oduA  ( 221 )    iIisklshs                     kghqkrkalktTviLilaFf
1u19A  ( 225 )    qLvftvkeaaaq------------qqesattqkaekevTrMviiMviaFl
2z73A  ( 222 )    nIvmsvsnhekemaamakrlnakelrkaqaganaemrlAkIsivIVsqFl
                  aaaaa                            aaaaaaaaaaaaaaaaa

                           310       320       330       340       350 
3uon   ( 398 )    itWapYNvmVlintfçap--------ç--ipntvwtiGywlCYinstiNp
4dajA  ( 501 )    itWtpyNimVlvntfçds--------ç--ipktywnlgywlCYiNStvNP
3rze   ( 426 )    lCWipYFiffmviafçkn--------ç--cnehlhmftiWlGYiNStlNP
2rh1   ( 284 )    lcWlpFFiVNivhviqdn----------lirkevyillNwiGYvNSgfNp
2vt4A  ( 301 )    lCWlpFFlvnivnvfnrd----------lvpdwlfvafnwlGYAnSAmnp
3pblA  ( 340 )    vCWlpFFltHvlnthçqt--------ç-hvspelysattwlGYvNsalNP
2ydv   ( 244 )    lCWlpLHiiNcftffçpd--------çshaplwlMylAivlSHtNSvvNP
3v2w   ( 267 )    acwapLFiLLllDvgçkvk------tç--diLfrAeyfLvlAvlNSgtNP
3oduA  ( 250 )    acWlpyyigisidsfilleiikqgçefentvhkwisitEAlAFfHCclNp
1u19A  ( 263 )    iCWlpYAgvAfyIfthqgsd---------fgpifMTipAFfAKtSAvyNP
2z73A  ( 272 )    lSWspYAvvAllAQfgplew---------VtpyaAQlpVMfAKaSaihNP
                  aaaaaaaaaaaaaaa                aaaaaaaaaaaaa   aaa

                           360       370       380       390       400 
3uon   ( 438 )    acYalcnatFkktfkhllm                               
4dajA  ( 541 )    vcYalcnktFrttfkt                                  
3rze   ( 466 )    liYplCnenFkktfkrilhi                              
2rh1   ( 324 )    liYc-rspdfriAfqellcl                              
2vt4A  ( 341 )    iiYc-rspdfrkAfkrlla                               
3pblA  ( 381 )    viYttfnieFrkAflkilsc                              
2ydv   ( 286 )    fiyAyrireFrqTFrkiirshvlrqqepfkaa                  
3v2w   ( 309 )    iiytltNkemrrafiri                                 
3oduA  ( 300 )    ilyaflgakfktsaqhalts                              
1u19A  ( 304 )    viYimmnkqFrnCmvttlccgknplgddeasttVsktetsqvapa     
2z73A  ( 313 )    miYsvsHpkFreAIsqtfpwvLtccqfddketeddkdaeteipage    
                  aaaaa  aaaaaaaaaa