The ChEMBL-og

There is a great meeting being held in Oxford just after the Christmas break (specifically on the 5th and 6th January 2012), it's organised by the Structural Genomics Consortium , one of the longest existing advocates of Open Science in Drug Discovery. Details of the meeting are here .

A meeting that may be of interest to many of you - the GCC 2011 7th German Conference on Chemoinformatics , to be held from November 6th to 8th 2011 in Goslar , Germany.

The EBI has a team entered for the annual Movember fund raising event - this is focussed on raising money for 'male cancers' - testicular and prostate . The team is called  The Bioinformoustachians!, so please consider sponsoring us over the coming month. Of course, as well as raising money for a serious cause, there will be some fun along the way as well. Watch over the next few days, as the full team signs up - we're gonna raise Loadsamoney (hopefully). For those unfamiliar with the idea - participants are clean shaved at the start and grow a moustache throughout the month gaining sponsorship for looking stylish/silly. The team webpage on the movember website is here . Please consider donating, and help us, together, make a difference.

ATC Code: N05BA09 Wikipedia: Clobazam On October 24 th , the FDA approved Clobazam (Tradename: Onfi TM ; Research Code: RU-4723), a GABA A receptor agonist, for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome ( LGS ) in patients aged two years or older. Lenox-Gastaut syndrome is a rare and severe form of epilepsy that is typically diagnosed in childhood and often persists into adulthood. LGS accounts for 1-4% of childhood epilepsies, and it is associated with multiple types of seizures, as well as, daily periods of frequent seizures. Clobazam decreases the frequency of the LGS seizures by potentiating GABAergic neurotransmission, trough the binding of the GABA A receptor at the benzodiazepine site. GABA A receptor is a protein complex of five subunits (mainly α2β2γ) located in the synapses of neurons. All GABA A receptors contain an ion channel that conducts chloride ions across neuronal cell membranes and two binding sites fo...

  ATC code  V03AC02   Wikipedia Deferiprone On October 14th, 2011 FDA announced the approval of Deferiprone ( trade name : Ferriprox TM ) for the treatment of iron overload which is potentially fatal in patients with thalassemia . Deferiprone is an oral iron chelating agent, binding excess iron in the blood and thus making it available to excretion from the body. Thalassaemia is a inherited (mostly autosomal recessive) blood disease that can lead to anemia by causing the formation of abnormal hemoglobin molecules not able to properly bind and release oxygen. Thalassaemia (OMIM: 141800 (α-) / 141900 (β-)) is sub-classified according to which of the subunits of the hetero-tetrameric (2α/2β, UniProt: P69905 / P68871 ) hemoglobin is affected, contrary to sickle-cell anaemia (OMIM: 603903 ) which results exclusively from a specific mutation in the β subunit. The primary treatment of thalassaemia major, the severe form of β-thalassaemia, requires frequent blood...

We have two posts available in the ChEMBL group - one a web developer, and the other a data integration post. The positions are both for three years and will be EMBL staff contracts. Closing dates for applications is the 27th November 2011 . Further details should be available here (the links are quite fragile I'm afraid, so sorry if they do not keep working for long) Web Developer  ( EBI_00145) Data Integration  ( EBI_00144) If you have any questions, please feel free to  contact us .

From the lab of one of our collaborators comes the following...... Details of forthcoming PhD studentships at The Institute of Cancer Research  ICR are now on-line ; There are 12 studentships across a range of different disciplines including Biology, Chemistry, Informatics and Medical Physics. The deadline for applications is 1st December 2011 . There is a specific studentship of likely interest to ChEMBL-og readers -  Identifying novel targets and target combinations for cancer using in-silico chemical biology , within the  Computational Biology and Chemogenomics Team of the ICR. This is a computational biology/lab biology PhD jointly between Dr. Bissan Al-Lazikani and Prof. Paul Workman. The project is an exciting multi-disciplnary project that will utilise bioinformatics and chemogenomics techniques, protein interaction network modelling as well as laboratory biology to identify novel drug intervention targets (and compounds) for use in combination therapie...