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Friday, 13 December 2019

Mechanism of Action and Drug Indication data on the interface.

Two new 'Browse' pages have been added to the interface; Browse Drug Mechanisms and Browse Drug Indications. Users can now access these 2 pages directly to explore all the data. Or alternatively, they can land on these pages from drugs, compounds and targets in ChEMBL.

Accessing all the data from the main page


The 'circles' visualisation on the main page shows a summary of the entities in ChEMBL. Circles for Drug Mechanisms of Action and Drug Indications have been added. By clicking on the circles, you will be taken to a page that allows you to explore the corresponding entity. 
Visualisation that summarises the entities in ChEMBL, Drug Mechanisms of Action and Drug Indications are now included.

The Browse Drug Mechanisms and Browse Drug Indications pages allow you to use filters, link to other entities, and download the data in the same way as the other 'Browse' pages.

All Drug Mechanism data.
All Drug Indication data.

Accessing Drug Indication and Drug Mechanism data related to other entities


You can now explore the Drug Indication and Drug Mechanism data in relation to the following entities:

From Browse Drug Mechanisms you can:
  • Browse related Drugs
  • Browse related Compounds
  • Browse related Targets

From Browse Drug Indications you can:
  • Browse related Drugs
  • Browse related Compounds

From Browse Drugs you can:
  • Browse related Drug Mechanisms
  • Browse related Drug Indications
  • Browse related Activities

Example A:


1. Go to the Browse Drug Mechanisms page. Find all drugs with mechanisms as neurokinin receptor antagonists.
Note that the data describes the mechanisms of action of 17 compounds for 3 targets.



2. Select all items and click on 'Browse Drugs', a new tab will open showing the drugs for the targets selected in step 1.



3. Click on 'Browse Drug Indications' to view all annotated indications for the drugs in step 2.




Example B:


1. Go to the Browse Drug Indications page. Find all drugs whose indication is asthma. There are 175 entries with asthma as an indication.



2. Select all items and click on 'Browse Drugs', a new tab will open showing the drugs for the indications selected in step 1.




3. Click on 'Browse Drug Mechanisms' to view of all annotated mechanisms for the drugs in step 2.



Accessing Drug Indication and Drug Mechanism data from report cards

You can now go to a dedicated page from the Drug Mechanism and Drug Indication data in the report cards. For example go to the report card for IMATINIB (CHEMBL941)

https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL941/

In the Drug Mechanism section you can see the data for that compound. If you click on 'Browse All', you will be directed to the Browse Drug Mechanisms page showing the data.

Drug Mechanisms section for the report card of IMATINIB (CHEMBL941)

Similarly, in the Drug Indications section you can click on 'Browse All' to be directed to a 'Browse Drug Indications' page showing all the data.
Drug Indications section for the report card of IMATINIB (CHEMBL941)


If you have any questions, please contact the ChEMBL Team support (chembl-help [at] ebi.ac.uk)




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