The ChEMBL-og

I put together a graph this afternoon, from home, with no real network connection, no database access and a sick dog - so treat the rendering of the data as preliminary, but I think it is quite interesting. Anyway, below is a retrospective view of 2008 US drug approvals. 10 Orals, 13 Parenterals and 1 Topical. 2 Natural Product derived drugs (excluding peptide drugs). All is well with the Rule of Five. 6 with black-box warnings. 1 new target (but quite a few with unknown mode of action). 20 small molecules, and 4 peptide/protein drugs.....

To make things a little simpler, and to allow rapid visual comparisons, we have set up a series of icons for our New Drug Approvals posts. These are very simple, and should be self explanatory. Three examples should make everything clear. A small molecule, Rule-of-Five compliant, oral drug A large molecule, parenteral drug, against a new target, with a black box warning. A natural product-derived topical drug Well maybe things are not as clear as could be..... but hey, you guys and gals are smart, and will soon work it out; and I am sure the magic blog pixies will add the correct icons to the previous posts.