ChEMBL extracts data from the core medicinal chemistry literature and therefore reflects ongoing developments in drug discovery. One area currently attracting high interest is targeted protein degradation: compounds that direct disease-causing proteins to the cell’s degradation machinery. These modalities are both present and rapidly increasing within ChEMBL, providing an important data source for the community. Targeted Protein Degradation Data in ChEMBL However, new and emerging modalities bring new challenges. Data should be well structured and FAIR, but for newer modalities, controlled vocabularies may not exist or adequately cover the breadth of data being reported. Cu ration effort in this area supports our broader goals towards generating bespoke datasets and improving AI-readiness. W e recently had the opportunity to attend the first ISCB UK conference where we presented our work towards the capture and annotatio...
Blog of Chemical Biology Services at EMBL-EBI