Skip to main content

New Drug Approvals - Pt. III - Golimumab (Simponi)

Third on our series of posts on new FDA drug approvals this year is Golimumab, approved on the 24th of April. Golimumab is a tumor necrosis factor alpha (TNF╬▒) blocker indicated for the treatment of active forms of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Golimumab is the fourth TNF inhibitor, after Etanercept, Infliximab and Adalimumab, to reach the market. Etanercept is a fusion protein of an engineered from the the TNF receptor fused to IgG1, while Infliximab and Adalimumab are very similar to Golimumab structurally in that they are all 'conventional' monoclonal antibodies. Golimumab (previously known as CNTO-148) is a human monoclonal antibody that exhibits multiple glycoforms with molecular weights of ca. 151 kDa. Golimumab has a good subcutaneous (sc) absorption (ca. 53% bioavailable), a plasma half-life of ca. 2 weeks, a volume of distribution of 58 to 126 mL/kg and a systemic clearance of 4.9 to 6.7 mL/day/kg. The recommended dosage of 50 mg is administrated by subcutaneous injection just once a month. The full prescribing information can be found here.

Golimumab has a boxed warning (colloquially known as a 'black box').

Golimumab is a monomeric immunoglobulin (IgG) consisting of four polypeptide chains in a "Y"- shaped form: two identical heavy chains of ~450 aminoacids and two identical light chains of ~217 animoacids, connected by disulfide bonds.

Golimumab molecular formula: C6530H10068N1752O2026S44

Golimumab CAS registry: 476181-74-5

The license holder for Golimumab is Centocor Ortho Biotech Inc. and the product website is


Popular posts from this blog

ChEMBL 34 is out!

We are delighted to announce the release of ChEMBL 34, which includes a full update to drug and clinical candidate drug data. This version of the database, prepared on 28/03/2024 contains:         2,431,025 compounds (of which 2,409,270 have mol files)         3,106,257 compound records (non-unique compounds)         20,772,701 activities         1,644,390 assays         15,598 targets         89,892 documents Data can be downloaded from the ChEMBL FTP site: Please see ChEMBL_34 release notes for full details of all changes in this release: New Data Sources European Medicines Agency (src_id = 66): European Medicines Agency's data correspond to EMA drugs prior to 20 January 2023 (excluding vaccines). 71 out of the 882 newly added EMA drugs are only authorised by EMA, rather than from other regulatory bodies e.g.

New SureChEMBL announcement

(Generated with DALL-E 3 ∙ 30 October 2023 at 1:48 pm) We have some very exciting news to report: the new SureChEMBL is now available! Hooray! What is SureChEMBL, you may ask. Good question! In our portfolio of chemical biology services, alongside our established database of bioactivity data for drug-like molecules ChEMBL , our dictionary of annotated small molecule entities ChEBI , and our compound cross-referencing system UniChem , we also deliver a database of annotated patents! Almost 10 years ago , EMBL-EBI acquired the SureChem system of chemically annotated patents and made this freely accessible in the public domain as SureChEMBL. Since then, our team has continued to maintain and deliver SureChEMBL. However, this has become increasingly challenging due to the complexities of the underlying codebase. We were awarded a Wellcome Trust grant in 2021 to completely overhaul SureChEMBL, with a new UI, backend infrastructure, and new f

Accessing SureChEMBL data in bulk

It is the peak of the summer (at least in this hemisphere) and many of our readers/users will be on holiday, perhaps on an island enjoying the sea. Luckily, for the rest of us there is still the 'sea' of SureChEMBL data that awaits to be enjoyed and explored for hidden 'treasures' (let me know if I pushed this analogy too far). See here and  here for a reminder of SureChEMBL is and what it does.  This wealth of (big) data can be accessed via the SureChEMBL interface , where users can submit quite sophisticated and granular queries by combining: i) Lucene fields against full-text and bibliographic metadata and ii) advanced structure query features against the annotated compound corpus. Examples of such queries will be the topic of a future post. Once the search results are back, users can browse through and export the chemistry from the patent(s) of interest. In addition to this functionality, we've been receiving user requests for  local (behind the