Three examples should make everything clear.
A small molecule, Rule-of-Five compliant, oral drug
A large molecule, parenteral drug, against a new target, with a black box warning.
A natural product-derived topical drug
Well maybe things are not as clear as could be..... but hey, you guys and gals are smart, and will soon work it out; and I am sure the magic blog pixies will add the correct icons to the previous posts.