Within the ChEMBL database we spend a lot of time manually curating links between FDA approved drugs and their efficacy targets. With collaborators from the University of New Mexico and the Institute of Cancer Research, we have now published an analysis of these drug efficacy targets: Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, Karlsson A, Al-Lazikani B, Hersey A, Oprea TI & Overington JP. A comprehensive map of molecular drug targets Nature Reviews Drug Discovery (2016) doi:10.1038/nrd.2016.230 In the article we address the complexities of assigning drug targets, describe the 667 human proteins and 189 pathogen proteins through which 1,578 FDA-approved drugs act and map each drug to its therapeutic indication via the WHO ATC classification system. We show that 70% of small molecule drugs still act through privileged families (GPCRs, ion channels, kinases and nuclear receptors), highlight the differences in innovation between different therapeutic areas,