The ChEMBL-og

Briefly, CORBEL is an initiative of thirteen biological and medical research infrastructures, which together create a platform for harmonised user access to biological and medical technologies, biological samples and data services required by cutting-edge biomedical research. Do you know that ChEMBL, through ELIXIR, participates to the project and provides its expertise in, among other things, identification of existing bioactivities for compounds of interest, profiling of chemotypes, target identification, data storage and distribution? But of course, CORBEL gives you access to different services working in many different biomedical areas. You want to screen the compounds you have identified and then use Electron Microscopy to observe their effect on a cell type of your interest, there are services for you! This is just an example of how CORBEL can contribute to boost your research projects(s), don’t forget we are   37 partners !   As part of the WP...

Our current tissue annotation efforts have been on increasing the breadth and depth of the tissue effort first started in ChEMBL 22. The figure above represents the increased depth and coverage from that initial point till now.  We continue to use a suite of tissue ontologies namely: Uberon, Experimental Factor Ontology ( http://www.ebi.ac.uk/ols/ontologies/efo ) , CALOHA (ftp://ftp.nextprot.org/pub/current_release/controlled_vocabularies/caloha.obo) and Brenda Tissue Ontology ( ( http://www.ebi.ac.uk/ols/ontologies/bto )   to identify assays where the tissue is the assay system. We have increased the detail of information we capture to reflect the more granular tissues mentioned in the assays such as 'Popliteal lymph node' and 'Substantia nigra' pars compacta where previously the higher level term ‘lymph node’ and ‘Substantia nigra’ might have been captured. Plasma based assays We have recently focused annotation efforts on plasma bas...