The ChEMBL database contains bioactivity data that links compounds to their biological targets. Most ChEMBL targets are proteins (~ 70% in version 27) and these are mapped to their UniProt accessions. On the ChEMBL interface, searches can be performed with either protein names or accessions...but did you know that protein similarity searches are also possible? Here’s an example using human Phospholipase DDHD2 , a target not found in ChEMBL. 1. On the ChEMBL interface , click 'Enter a Sequence: 2. Input the FASTA sequence corresponding to human Phospholipase DDHD2 and click 'Search in ChEMBL': 3. Review the BLAST results, select targets of interest and browse bioactivity data: The BLAST search identifies the mouse Phospholipase DDHD2 homologue alongside a small number of bioactivity data points and active compounds . ChE...
The Organization of Drug Discovery Data
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