Well, there's a great paper in a recent Nature Reviews Drug Discovery from a cross-industry set of authors on a retrospective analysis of HTS in drug discovery - lots of data, lots of examples, and a balanced argument for the case for high-throughput screening in modern pharmaceutical discovery.
%T Impact of high-throughput screening in biomedical research %J Nature Rev. Drug Disc. %V 10 %D 2012 %P 188-195 %A R. Macarron %A M.N. Banks %A D. Bojanic %A D.J. Burns %A D.A. Cirovic %A T. Garyantes %A D.V.S. Green %A R.P. Hertzberg %A W.P. Janzen %A J.W. Paslay %A U. Schopfer %A G.S. Sittampalam