How do I get a reasonably complete, reasonably accurate list of PPIs?

A recurring thing we are interested in is classifying the natural ligand/partner of a protein. Having a classification of the 'natural' ligand partner for every human protein would be really useful, and would allow us to ask and more importantly answer quite complex questions in ChEMBL like - 'show me all small molecules that modulate a protein-protein interaction (PPI) at better than 100 nM potency?'.

I've had a bit of a dig around the web, but there isn't anything that does exactly what I need (or I'm not smart enough to find it), but I'm sure it must exist, so in the comments section, please post resources and ideas.....

Comments

DGA said…

'show me all small molecules that modulate a protein-protein interaction (PPI) at better than 100 nM potency'

hope this helps: TIMBAL holds small molecules disrupting protein-protein interactions

http://www-cryst.bioc.cam.ac.uk/databases/timbal

David, Biomol Informatics

25 May 2011 at 14:12

jpo said…

Thx!

26 May 2011 at 05:49

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