Updated drug safety information is available (as of ChEMBL 28) for drugs with boxed warnings and for withdrawn drugs.
Boxed warnings (also know as black box warnings) are provided on medicinal product labels for FDA approved drugs if the medicinal product can cause severe or life-threatening side effects. They are free text descriptions, enclosed within a black box, hence the name! For example, Oxaprozin is used to treat osteoarthritis but carries a boxed warning.Our recent work has classified the type of adverse effect described in boxed warnings on a per drug basis. For medicinal products that contain one active pharmaceutical ingredient, a boxed warning can be directly linked to a drug. Therefore, toxicity class(es) have been assigned to approved drugs with boxed warning information described on medicinal product labels (e.g. Cardiotoxicity, Hepatotoxicity etc). Clickable links to examples of medicinal product labels with boxed warning text descriptions have been retained to allow database users to drill down through the information “audit trail” to examine the source information. Further details are available from Hunter et al., 2021.