Papers: Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets
There's a really interesting paper just published in Science on the screening of the NCGC drug collection against the malaria parasite, it's a tour de force in the application of screening and genomics analysis/exploration of bioactivity data. Amongst the 32 highly actives there are mostly cytotoxic agents, which are probably no big surprise, but a couple of interesting things in there, more later on this (probably...)
Anyway the paper is here.
%T Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets %J Science %V 333 %P 724-729 %D 2011 %A J. Yuan %A K.C.-C. Cheng %A R.L. Johnson %A R. Huang %A S. Pattaradilokrat %A A. Liu %A R. Guha %A D.A. Fidock %A J. Inglese %A T.E. Wellems %A C.P. Austin %A X.Z Su