ChEMBL Resources

Resources:
ChEMBL
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SureChEMBL
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ChEMBL-NTD
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ChEMBL-Malaria
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The SARfaris: GPCR, Kinase, ADME
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UniChem
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DrugEBIlity
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ECBD

Saturday, 6 August 2011

Papers: Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets



There's a really interesting paper just published in Science on the screening of the NCGC drug collection against the malaria parasite, it's a tour de force in the application of screening and genomics analysis/exploration of bioactivity data. Amongst the 32 highly actives there are mostly cytotoxic agents, which are probably no big surprise, but a couple of interesting things in there, more later on this (probably...)

Anyway the paper is here.

%T Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets
%J Science
%V 333
%P 724-729
%D 2011
%A J. Yuan
%A K.C.-C. Cheng
%A R.L. Johnson
%A R. Huang
%A S. Pattaradilokrat
%A A. Liu
%A R. Guha
%A D.A. Fidock
%A J. Inglese
%A T.E. Wellems
%A C.P. Austin
%A X.Z Su

1 comment:

Christophe said...

I checked the reported hits with Google Scholar.
It appears that all hits except for ALAZANINE
and LESTAURNIB have been reported as having anti-malarial properties in the lit. before.