ChEMBL Resources

Resources:
ChEMBL
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SureChEMBL
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ChEMBL-NTD
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ChEMBL-Malaria
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The SARfaris: GPCR, Kinase, ADME
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UniChem
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DrugEBIlity
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ECBD

Tuesday, 22 March 2011

A Taxonomy for Drugs: 3 - Antibody subtypes


There is an excellent description of specific subtypes of monoclonal antibodies on Wikipedia, these can be easily incorporated into the Drug_Class section of our drug taxonomy. Specifically as Drug_Type_Subsubclass. An interesting property of this classification is that it should be possible to write an algorithm that classifies arbitrary sequences against this taxonomy.


  • mab - whole monoclonal antibody.
  • Fab - fragment, antigen-binding (one arm).
  • F(ab')2 - fragment, antigen-binding, including hinge region (both arms).
  • Fab' - fragment, antigen-binding, including hinge region (one arm).
  • scFv - single-chain variable fragment.
  • di-scFv - dimeric single-chain variable fragment.
  • sdAb - single-domain antibody.
  • 3funct - trifunctional antibody.
  • BiTE - bi-specific T-cell engager.
  • Other - an antibody like drug that does not fit one of the above classes.

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