There is an excellent description of specific subtypes of monoclonal antibodies on Wikipedia, these can be easily incorporated into the Drug_Class section of our drug taxonomy. Specifically as Drug_Type_Subsubclass. An interesting property of this classification is that it should be possible to write an algorithm that classifies arbitrary sequences against this taxonomy.
- mab - whole monoclonal antibody.
- Fab - fragment, antigen-binding (one arm).
- F(ab')2 - fragment, antigen-binding, including hinge region (both arms).
- Fab' - fragment, antigen-binding, including hinge region (one arm).
- scFv - single-chain variable fragment.
- di-scFv - dimeric single-chain variable fragment.
- sdAb - single-domain antibody.
- 3funct - trifunctional antibody.
- BiTE - bi-specific T-cell engager.
- Other - an antibody like drug that does not fit one of the above classes.
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