It is intuitive to describe what a drug is in natural language - a small molecule, etc, but one problem is that these descriptive terms are context dependent, loosely defined and are used very variably across the literature; and so when someone asks 'How many small molecule drugs there are?' - first of all it depends on what is a 'drug', and secondly what is a 'small molecule'. As far as I can tell there is not a descriptive taxonomy for drugs (I use the term taxonomy here as a bridge term between a controlled vocabulary/dictionary and an ontology). For our own purposes within ChEMBL we need such a taxonomy, but post our initial thoughts here for comment, and no doubt (and hopefully), significant correction and improvement (use the comment section of the blog, then everyone can see any discussions).
Drugs are regulated products that are 'intended use in the diagnosis, cure, mitigation, treatment or prevention of disease' - let's not visit what a disease is, but move swiftly on to trying to sub divide this into obvious and useful categories/classes when thinking about molecular drug structures.
So for a Drug_Class, categorisation into the following seems intuitive and useful. Most of the action in drug discovery will be connected to the "Therapeutic" class.
- Therapeutic - A substance with a curative action on a disease.
- Supplement - A substance, used to address a deficiency of that substance (or of that substances normal function).
- Imaging Agent - A substance used to image a molecule or structure within the body.
- Diagnostic Agent - A substance used in the diagnosis of a disease, not involving imaging.
- Other - A substance not covered by the categories above.
- Small Molecule - A substance with a molecular weight less than 1500 Da that is otherwise not a Biological.
- Biological - A substance primarily composed from monomers of naturally occuring substances (e.g. amino-acids, sugars, nucleotides, etc.).
- Other - A substance not covered by the categories above.
For Small Molecules:
- Inorganic - A non-organic substance.
- Natural Product-derived - A substance that is derived from a naturally occurring primary or secondary metabolite.
- Synthetic - An organic substance that is not derived from a naturally occurring priamry or secondary metabolite.
- Other - A substance that is a Small Molecule which is not covered by the categories above.
- Monoclonal antibody (mAb) - A substance similar in sequence to an antibody sequence.
- Vaccine - A substance that acts through eliciting an acquired immune response in the patient.
- Enzyme - A substance acting as a catalyst for a chemical reaction.
- Virus - A substance with the biological characteristics of a competant virus.
- Cell - A substance with the biological characteristics of a competant cell.
- Peptide - A substance which is a polymer built primarily from amino acids, containing between two and twenty amino acids.
- Protein - A substance which is a polymer built primarily from amino acids, containing in excess of twenty amino acids, and that is not a monoclonal antibody.
- Oligosaccharide - A substance which is a polymer built primarily from sugar-like monomers.
- Oligonucleotide - A substance which is a polymer built primarily from nucleotide-like monomers.
- Other - A substance which is not covered by the categories above.
For example:
Sildenafil is a "synthetic small molecule therapeutic"
Abciximab is a "monoclonal antibody biological therapeutic".
Vitamin D3 is a "natural product-derived small molecule supplement".
Ioflupane 123I is a "synthetic small molecule imaging agent"
Any feedback, pointers to any existing classifications/taxonomies, etc. would be very welcome.
Parts 2, 3 and 4 for this Drug taxonomy will be posted shortly.
Comments
Therefore, we could have a general definition of drug along the lines of
Def= A drug is a role borne by a material that is realized (the material is classified as a drug when) in a process of absorption by an organism or an entity of organism origin (i.e. cell line) that, alters, or effects a function or functions which inhere in the organism or entity of organism origin.
Then your definition of a drug could be a subclass of drug and be called, regulated_drug with the following definition.
Def= A regulated_drug is a drug (def above) that has an intended use in the diagnosis, cure, mitigation, treatment or prevention of disease and is regulated or approved by an regulatory organisation/authority.
For the rest of the definitions it may be helpful to think in terms of both the physical thing that has the role drug and the process that occurs, so for example you have the process Therapeutic_effect and a therapeutic is a drug that acts as a participant in the therapeutic_effect_process to cause/contribute to the therapeutic_effect observed.
For imaging and diagnostics it may be helpful to think of these materials as a proxy for the end result. i.e. facilitates imaging, or facilitates a diagnosis by proxy.
P.S I don't know what "naturally" means in relation to supplement, I am not sure I would describe Berocca as natural :)
Our use of the word drug within the group refers to a regulated substance, with a defined chemical composition (biologicals ften do not have a completely characterised composition, and can be a population of closely related chemical species).
Before Drugs come Clinical Candidates, and these have their own definitions, accepted terms, etc. This is another area where we are developing a taxonomy, as are the therapeutic effects you mention.
Naturally occurring is a difficult thing as well when you want to pin a precise definition to it. For us, the intent is to capture cases where the molecule either is, or is closely chemically related to, a natural metabolite. If this naturally occurring molecule has some therapeutic effect, and requires being regulated by the FDA, EMEA, etc. - So I guess the commercial product you mention will be out of scope.
mab: whole monoclonal antibody
F(ab')2: fragment, antigen-binding, including hinge region (both arms)
Fab': fragment, antigen-binding, including hinge region (one arm)
scFv: single-chain variable fragment
di-scFv: dimeric single-chain variable fragment
sdAb: single-domain antibody
3funct: trifunctional antibody
BiTE: bi-specific T-cell engager